Malyugin B.E. is having great innovative potential. He put a lot of efforts into the development of new diagnostic and treatment methods, as well as the creation of original microsurgical instruments. He is the author of over 200 Russian and several international patents.

Patents list:

1. No.2055519 dated 04.13.1993. Method for determining the radius of curvature of an opaque cornea.
2. No. 2066163 dated 04.13.1993. Method for surgical correction of astigmatism after penetrating keratoplasty.
3. No. 2070013 dated 02.26.1993. Method of implantation of the posterior chamber artificial lens.
4. No. 2102952 dated 08.09.1995. Method of pupil dilation during ophthalmic surgery.
5. No. 2103966 dated 08.09.1995. Method of pupil dilation during ophthalmic surgery.
6. No. 2134090 dated 09.27.1996. Method for preventing an increase in intraocular pressure after phacoemulsification of a cataract with IOL implantation.
7. No.2155566 dated 10.30.1996. Method for surgical treatment of open-angle glaucoma and cataract with intraocular lens implantation.
8. No. 2135130 dated 12.24.1996. Method of implantation of an artificial lens into the eye.
9.No. 2149612 dated 25.11.1997. Method for cataract extraction with implantation of an artificial lens.
10.No. 2149613 dated 25.11.1997. Method for cataract extraction with implantation of an artificial lens.
11. No.2148974 dated 11.25.1997. Method for cataract extraction with implantation of an artificial lens.
12.No. 2139019 dated 04.22.1998. A device for the implantation of flexible artificial eye lenses.
13.No. 2161464 dated 02.07.1998. Method of pain relief in ophthalmology.
14. No.2165248 dated 04.29.1998. A method for the surgical treatment of high astigmatism and cataract.
15.No. 2173126 dated 06.08.1998. Method of implantation of an artificial lens in violation of the integrity of the capsular bag.
16.No. 2172151 dated October 29, 1998. Method of medical expansion of the pupil in ophthalmology.
17.No. 2172154 dated 02.07.1998. Cataract extraction method by phacoemulsification.
18. No. 2147876 dated 07.08.1999. Pharmaceutical composition for pain relief in ophthalmology.
19.No. 2148404 dated 07.08.1999. Pharmaceutical composition for drug-induced pupil dilation in ophthalmology.
20.No. 2172156 dated 02.04.1999. Method for the surgical treatment of retinal detachment.
21. No. 2173127 dated 24.06.1999. Method for removing the lens from the vitreous cavity.
22. No. 2173957 dated 07.08.1999. Method for determining indications for phacoemulsification
23. No. 2196551 dated 29.03.2000. Method of surgical treatment of presbyopia and an intrascleral implant for its implementation.
24. No. 2196553 dated 27.10.2000. Method for performing a surgical incision during cataract extraction.
25. No. 2197203 dated July 26, 2000. Cataract extraction method.
26. No. 2183114 dated 05.11.2001. Pharmaceutical composition for prolonged pain relief in ophthalmology “Polyanesthetic”.
27. No. 2195904 dated July 30, 2001. Method for preventing an increase in intraocular pressure after phacoemulsification of a cataract with implantation of an intraocular lens.
28. No. 2195906 dated 06.09.2001. Method for treating hypertension after phacoemulsification of cataracts in eyes with glaucoma.
29. No. 2196542 dated March 14, 2001. Artificial lens of the eye and method of its implantation
29. No. 2197923 dated 25.05.2001. Pharmaceutical composition for the treatment of corneal edema “Osmogel”.
31. No.2198639 dated March 14, 2001. A method for the simultaneous surgical treatment of cataract and astigmatism.
32. No.2198640 from 30.07.2001. A method for the surgical treatment of open-angle glaucoma.
33. No. 2202987 dated 17.04.2001. Method of preventing rotation of a sphero-cylindrical intraocular lens with intracapsular fixation.
34. No. 2202989 dated 04.07.2001. Artificial lens of the eye.
35. No. 2203638 dated 06.09.2001. Method for the surgical treatment of open-angle glaucoma.
36. No 2204366 dated 03.10.2001. Method for the surgical treatment of glaucoma.
37. No. 2211012 dated 01.11.2001. Intrascleral implant for surgical treatment of presbyopia combined with open-angle glaucoma, and the method of its implantation.
38. No. 2211687 dated 01.11.2001. Method for the treatment of retinal detachment.
39. No. 2212883 dated 01.11.2001. Irrigation composition for intraocular use “Hydroelastic”
40. No. 2223721 dated 27.04.2002. Artificial lens of the eye and the method of its implantation.
41. No. 2223722 dated 18.07.2002. Artificial lens of the eye.
42. No. 2234896 dated 24.12.2002. Method of simultaneous surgical treatment of involutional changes in the lacrimal dots and lacrimal canaliculus, combined with age-related cataract, and the implantation of an intraocular lens.
43. No. 2234897 dated 24.12.2002. A method of simultaneous surgical treatment of cicatricial lesions of the lacrimal canaliculus, combined with cataract, and implantation of an intraocular lens.
44. No. 2234898 dated 24.12.2002. A method of performing a surgical incision in glaucoma combined with dry eye syndrome
45. No. 2234899 dated 24.122002. Method for simultaneous surgical treatment of dry eye syndrome combined with cataract in non-stabilized glaucoma with intraocular lens implantation.
46. No. 2236200 dated 24.12.2002. Method for measuring the amount of main tear production and taking unstimulated tears.
47. No. 2238066 dated 05.11.2002. Method of subtotal vitrectomy.
48. No. 2231334 dated 30.01.2003. Artificial lens of the eye.
49. No. 2239391 dated 18.06.2003. Method for making an artificial lens of an eye and an artificial lens of an eye.
40. No. 2242189 dated 07.08.2003. Method for making an artificial lens of an eye and an artificial lens of an eye.
51. No. 2242193 dated 10.04.2003. Method of cataract extraction with IOL implantation.
52. No. 2254110 dated 26.11.2003. Method of protecting tissues of the anterior segment of the eyeball in cataract surgery.
53. No. 2260407 dated 29.12.2003. Method for cataract extraction with intraocular lens implantation.
54. No. 2271151 dated 22.06.2004. Method for determining the differential diagnosis of a violation of the balance of the outflow-inflow of the tear fluid due to the pathology of the lacrimal system or due to the pathology of the lacrimal canal.
55. No. 2271174 dated 07.07.2004. Artificial lens of the eye.
56. No. 2271180 dated 10.06.2004. Method of repositioning a dislocated intraocular lens.
57. No. 2281739 dated 22.06.2004. Method of simultaneous surgical treatment of dry eye syndrome combined with pterygium.
58. No. 2284181 dated 11.11.2004. Pharmaceutical composition for infection prevention in ophthalmology “Intravisc”.
59. No. 2293546 dated 02.08.2005. A method for the surgical treatment of vitreous opacity combined with cataracts.
60. No. 2295941 dated 07.09.2005. Method of cataract extraction with intraocular lens implantation with a narrow pupil and a device for its implementation.
61. No. 2300352 dated 07.09.2005. A method for the simultaneous surgical treatment of cataract combined with open- or narrow-angle glaucoma using a single surgical approach and implantation of an intraocular lens.
62. No. 2317047 dated 26.10.2006. Method for the surgical treatment of open-angle glaucoma.
63. No. 2317048 dated 26.10.2006. Method for the surgical treatment of open-angle glaucoma.
64. No. 2362524 dated 05.03.2008. Method for cataract extraction vitrectomy and intraocular lens implantation.
65. No. 2366383 dated May 14, 2008. Artificial lens of the eye for the correction of high myopia.
66. No. 2375996 dated 14.08.2008. Method of repositioning an intraocular lens, dislocated or decentralized with the capsule bag.
67. No. 2376001 dated 14.08.2008. Method for improving visual functions after implantation of a multifocal intraocular lens.
68. No. 2376961 dated 09.07.2008. Method for cataract extraction with implantation of an artificial lens of the eye.
69. No. 2376962 dated 16.09.2008. Method of phacoemulsification of cataracts with subluxation of the lens due to weakness of the Zinn zonules or their rupture.
70. No. 2377964 dated 19.03.2008. Artificial lens of the eye.
71. No. 2388437 dated 04.16.2009. Method for determining the size of the posterior phakic intraocular lens.
72. No. 2400190 dated 28.05.2009. Method for determining differentiated indications for the choice of the method of treatment of initial and advanced keratoconus.
73. No. 2407424 dated 28.07.2009. Method for early diagnosis of changes in the position of the artificial lens of the eye in the eye.
74. No. 2407442 dated 28.07.2009. Method for early diagnosis of the state of the cataract capsule of the lens.
75. No. 2434615 dated 21.07.2010. Method for phacoemulsification of cataract in patients with congenital lens dysplasia and pathology of its ligamentous apparatus.
76. No. 2444340 from 15.09.2010. Method of keratoprosthetics of complicated vascular leucoma using biokeratoprosthetic complex.
77. No. 2444341 from 15.09.2010. Posterior lamellar keratoplasty method.
78. No. 2450515 dated 01.12.2010. Media for the donor cornea preservation.
79. No. 2455923 from 23.03.2011. Method for diagnosing myopizing phacoclerosis.
80. No. 2455965 from 23.03.2011. Method for anterior deep lamellar keratoplasty.
81. No. 2458661 from 23.03.2011. The method of phacoemulsification of cataract in patients with extensive defects of the lens ligamentous apparatus.
82. No. 2475218 dated 06.12.2011. Method of isolation and organo-typical preservation of allogeneic limbal graft.
83. No. 2484793 dated 28.03.2012. Method for correcting bilateral aphakia.
84. No. 2508074 dated 21.08.2012. Accommodating artificial lens of the eye.
85. No. 2508076 dated 16.05.2012. Accommodating artificial eye lens and method of its implantation.
86. No. 2513673 dated 27.12.2012. Artificial Iris implant cartridge.
87. No. 2513950 dated 27.12.2012. A cartridge for the implantation of an artificial lens of the eye.
88. No. 2515528 dated 05.12.2012. Instrument for performing ophthalmic microsurgery.
89. No. 2525657 dated 05.12.2012. Instrument for performing ophthalmic microsurgery. 89. No. 2521834 dated 21.08.2012. Method for determining the diameter of the ciliary sulcus by optical coherence tomography of the anterior segment of the eye.
90. No. 2513687 dated 24.01.2013. Irrigation device.
91. No. 2521844 dated 04.08.2013. Method for choosing parameters for laser treatment of terminal stages of glaucoma.
92. No. 2523144 dated 04.08.2013. Artificial lens of the eye for fixation on the edge of the anterior capsulorhexis and / or in the ciliary sulcus.
93. No. 2523148 of 01.24.2013 Ophthalmic microsurgical knife.
94. No. 2523149 dated 24.01.2013. Ophthalmic microsurgical knife.
95. No. 2523341 dated 24.01.2013. Ophthalmic microsurgical knife.
96. No. 2523342 dated 13.02.2013. Method of keratoprosthetics of complicated vascular leucoma of 4-5 categories.
97. No. 2525382 dated 03.05.2013. Irrigation device.
98. No. 2528649 dated 04.07.2013. Corneal segment for the treatment of keratectasia of various origin.
99. No. 2529787 dated 03.06.2013. Ophthalmic irrigation solution.
100. No. 2531464 dated 02.08.2013. Artificial lens of the eye.
101. No. 253147 dated 04.07.2013. Instrument for scarification of the corneal epithelium.
102. No. 2531472 dated 02.08.2013. Artificial lens of the eye.
103. No. 2532288 dated 24.07.2013. Ophthalmic microsurgical knife
104. No. 2534394 dated 03.05.2013. Irrigation device.
105. No. 2536710 dated 02.08.2013. Artificial lens of the eye.
106. No. 2538242 dated 02.08.2013. Artificial lens of the eye.
107. No. 2541815 dated 24.07.2013. Ophthalmic microsurgical knife.
108. No. 2541817 dated 02.08.2013. Pusher for artificial eye implant.
109. No. 2544097 dated 04.07.2013. Intracorneal lens for presbyopia correction.
110. No. 2548516 dated 07.24.2013. Irrigation device.
111. No. 2550002 dated 02.08.2013. Artificial lens of the eye.
112. No. 2552315 dated 07.24.2013. Irrigation device.
113. No. 2559177 dated 09.06.2014. Method for implantation of a flexible pupillary intraocular lens model RSP-3 after micro-coaxial cataract phacoemulsification.
114. No. 2576818 dated 27.04.2015. Method for surgical treatment of primary open-angle glaucoma.
115. No. 2613443 dated December 29, 2015. A device for plastics of defects and deformations of the bottom of the orbit and the method of its use.
116. No. 2597569 dated 09.07.2015. Method for predicting the safe position of the Cachet anterior chamber phakic intraocular lens.
117. No. 2600158 dated 17.09.2015. Method of Descemet’s membrane transplantation.
118. No. 2617094 dated December 29, 2015. A device for plastics of defects and deformations of the bottom of the orbit and the method of its use.
119. No. 2613437 dated 17.12.2015. The method of femtosecond laser phacoemulsification with a narrow rigid and decentralized pupil.
120. No. 2613415 dated 28.01.2016. Method for eliminating eyelid retraction in endocrine ophthalmopathy.
121. No. 2613442 dated 28.04.2016. Method of treating a donor cornea with bilateral ultraviolet crosslinking for keratoprosthetics of complicated vascular leucoma of 4-5 categories.
122. No. 2617067 dated 01.04.2016. Method for predicting the level of intraocular pressure in patients with cataracts against the background of pseudoexfoliation syndrome with ophthalmic hypertension before surgery 3 months after phacoemulsification.
123. No. 2617091 dated 11.02.2016. Method for predicting the level of intraocular pressure (IOP) in patients with cataracts against the background of pseudoexfoliative syndrome with a normal level of IOP before surgery in the first 5 days after phacoemulsification.
124. No. 2617094 dated December 29, 2015. A device for plastic of the defects and deformations of the bottom of the orbit and the method of its use.
125. No. 2620248 dated 28.01.2016. Method for eliminating paralytic lagophthalmos.
126. No. 2620307 dated 06.16.2016. Method for removing emulsified silicone oil from the vitreous cavity.
127. No. 2625781 dated June 16, 2016. Method for implantation of an intraocular lens after micro-coaxial phacoemulsification of cataract with extensive defects of the ligamentous apparatus of the lens.
128. No. 2629211 dated 06.10.2016. A method for preparing ultrathin donor corneal grafts for posterior lamellar keratoplasty by the method of sequential application of an automatic microkeratome and an excimer laser.
129. No. 2630035 dated 17.11.2016. Method for the treatment of combined pathology of the early stage of primary endothelial dystrophy of the Fuchs cornea and cataract.
130. No. 2633341 dated 06.10.2016. Method of preparing ultrathin donor corneal grafts for posterior lamellar keratoplasty by the method of sequential application of an automatic microkeratome and two-stage photoablation using an excimer laser.
131. No. 2644301 dated 05.25.2017. Method for diagnosing the progression of the “glistening” effect in the substance of an intraocular lens in vivo.
132. No. 2644850 dated 20.04.2017. Method of creating an intrastromal pocket for keratoprosthesis implantation using a femtosecond laser.
133. No. 2646588 dated March 21, 2017. Method of carrying out keratoplasty with simultaneous implantation of the intrastromal ring.
134. No. 2652753 dated 16.02.2017. Method of preparing ultrathin donor corneal grafts for posterior lamellar keratoplasty by the method of sequential application of a femtosecond and excimer laser using a hyperopic ablation profile.
135. No. 2655114 dated 13.07.2017. Method of femtosecond laser phacoemulsification with decentration of the pupil relative to the center of the lens.
136. No. 2662420 dated June 29, 2017. Intraocular lens removal method.
137. No. 2665677 dated 19.10.2017. Method for personalized determination of the optical power of an intraocular lens with intracapsular fixation in patients with keratectasia.
138. No. 2668704 dated 07.12.2017. Method for differential diagnosis of capsule block syndrome and non-adherence of the posterior lens capsule in the late postoperative period.
139. No. 2674585 dated 09.11.2017. Media for the preservation of the donor cornea.
140. No. 2676311 from 15.02.2018. Media for the preservation of the posterior lamellar graft of the donor cornea.
141. No. 2676451 dated 03.19.2018. Method of corneal collagen crosslinking using femtosecond laser.
142. No. 2682495 dated 02.08.2018. Method of cutting out the Descemet’s membrane and endothelium graft.
143. No. 2689015 dated 17.052018. Combined method of treating patients with primary open-angle glaucoma and complicated cataract.
144. No. 2689884 dated 18.01.2018. Method of preparing ultrathin donor corneal grafts for posterior lamellar keratoplasty with endothelial access using a high-energy femtosecond laser.
145. No. 2695628 dated July 26, 2018. Method of performing anterior deep lamellar keratoplasty using a low-energy femtosecond laser.
146. No. 2698365 dated 12.24.2018. Method for assessing the dynamic position of an intraocular lens.
147. No. 2698448 dated 12.02.2019. Method for trans-vitreal fine-needle aspiration biopsy of intraocular tumors.
148. No. 2699534 dated 16.05.2019. Method of implantation of the intracapsular ring.
149. No. 2702321 dated 12.02.2019. Method for the treatment of Descemet’s membrane detachment.
150. No. 2712301 dated 16.05.2019. Method for assessing the angle of deflection of an intraocular lens using optical coherence tomography.
151. No. 2719913 dated 12.04.2019. Method for fixing incompetent keratotomy scars in patients in the long-term period after anterior radial keratotomy.
152. No. 2727871 dated 14.01.2020. Method of preparing ultrathin grafts for posterior lamellar keratoplasty.
153. No. 2727873 dated January 22, 2020. Method for expert assessment of visual acuity.
154. No. 2727873 of 22.01.2020. Method for expert assessment of visual acuity.
155. No. 2739130 of 03.03.2020. Thin-walled needle for biopsy of intraocular neoplasms and method for choosing the angle of cut of the working end of the needle.
156. No. 2741411 dated 30.07.2020. A method for reconstructing the corneal epithelium in unilateral limbal insufficiency syndrome.
157. No. 2745114 dated 08.12.2020. Means for organotypic preservation of the donor cornea.
158. Patent No. 2754514 dated 15.12.2020. Method for surgical treatment of rhegmatogenous retinal detachment complicated by macular rupture.
159. Patent No. 2754517 dated 27.01.2021. A method for phacoemulsification of cataracts that provides prevention and relief of the syndrome of intraoperative deviation of the irrigation flow.
160. Patent No. 2758027 dated 04.02.2021. Method for cataract phacoemulsification in patients with corneal opacity.
161. Patent No. 2758028 dated March 16, 2021. Method for performing posterior layered keratoplasty using a femtosecond laser.
162. Patent No. 2752547 dated 03.04.2021. Method for leveling the surface of the cornea with micro boron in the surgical treatment of limbal insufficiency syndrome and/or the presence of corneal calcifications (Variants).

Utility model patents & certificates:

1. No. 9157 dated 07.15.1998. A device for expanding the capsular bag during the implantation of an artificial lens of the eye.
2. No. 9582 dated 09.15.1998. A device for the implantation of an eye capsule dilator.
3. No. 9720 dated 09.15.1998. Pupil dilator.
4. No. 11054 dated 02.04.1999. Corneal implant
5. No. 11702 dated 05.27.1999. Circular notch marker
6. No. 12006 dated 24.06.1999. Needle for ultrasonic phacoemulsification handpiece.
7. No. 12007 dated 24.06.1999. Device for manipulating fragments of the lens nucleus.
8. No. 12009 dated 24.06.1999. Device for separating the nucleus of the lens.
9. No. 12011 dated 06.07.1999. Lens splitter.
10. No. 12013 dated 06.07.1999. Needle for ultrasonic phacoemulsification handpiece.
11. No. 12014 dated 07.08.1999. Hydrodissection cannula.
12. No. 12016 dated 07.08.1999. Microsurgical blade.
13. No. 12784 dated 21.10.1999. Spatula for eye microsurgical operations.
14. No. 12785 dated 21.10.1999. Spatula for eye microsurgical operations.
15. No. 12786 dated 10.21.1999. Lens aspiration device
16. No. 12787 dated 10.21.1999. Irrigation device for the anterior chamber of the eye
17. No. 13152 dated 21.10.1999. Needle for ultrasonic phacoemulsification handpiece.
18. No. 13317 dated 12.16.1999. Artificial lens of the eye.
19. No. 14506 dated 02.24.2000. Pupil dilator.
20. No. 15958 dated 08.10.2000. A device for manipulating the lens.
21. No. 16337 dated 08.10.2000. Device for fixing the pupillary model of the artificial lens of the eye.
22. No. 16338 dated 08.10.2000. Microsurgical delaminating blade.
23. No. 16339 dated 08.10.2000. Pupil dilator.
24. No. 17420 from 26.06.2000. Device for marking the corneal tunnel during phacoemulsification.
25. No. 18343 dated 12.27.2000. Device for scleral marking during cataract extraction and intraocular lens implantation.
26. No. 19749 dated 12.16.1999. Artificial lens of the eye.
27. No. 20725 dated 30.07.2001. Device for vacuum aspiration of the anterior chamber angle and the trabecular zone of the eye.
28. No. 22872 dated November 27, 2001. Capsule bag expansion device.
29. No. 23564 dated 19.12.2001. Device for fixing the artificial lens of the eye.
30. No. 24375 dated 08.10.2000. Artificial iris.
31. No. 25160 dated 04.27.2002. Artificial lens of the eye.
32. No. 25161 dated 04.27.2002. Artificial lens of the eye.
33. No. 25162 dated 04.27.2002. Device for the implantation of an artificial lens of the eye.
34. No. 25267 dated 04.27.2002. Artificial lens of the eye.
35. No. 30077 dated 12.24.2002. Probe for the introduction of a blocker and intubation of the lacrimal canaliculus.
36. No. 30078 dated 12.24.2002. Compass probe.
37. No. 30079 dated 12.24.2002. Cannula probe for the diagnosis and treatment of diseases of the lacrimal duct.
38. No. 30080 dated 12.24.2002. Universal probe for the lacrimal duct.
39. No. 30081 dated 12.24.2002. Lacrimal duct blocker.
40. No. 30082 dated 30.01.2003. Artificial lens of the eye.
41. No. 32995 dated 05.08.2003. Artificial lens of the eye.
42. No. 128495 12.05.2012. Capsule bag expansion device.
43. No. 131613 dated 24.01.2013. Forceps to remove the anterior chamber phakic intraocular lens.
44. No. 132989 dated 05.07.2013. Micro-instrument for endothelial keratoplasty.
45. No. 138752 dated 23.10.2013. Irido-capsular retractor
46. No. 168368 dated 03.16.2016. Microsurgical spatula for opening the corneal femtosecond laser incision.
47. No. 177228 dated 05.10.2017. Microsurgical cannula for staining the anterior lens capsule.